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Cartoon of the process of diploidization following a whole genome duplication event.

The process of a polyploid genome returned to a diploid status. While the overall gene content is reduced to one that is similar to the pre-duplicated ancestory, the overall architecture of the genome will be vastly different due to fractionation of gene content from homeologous genomic regions, transposition events, and large-scale genomic changes such chromosomal rearrangements. Also, some gene families tend to be retained their duplicate copies following polyploidy events.