In-Paralog: Difference between revisions

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[[Image:otu.png|thumb|right|500px|Diagram depicting evolutionary relationship between orthologs, in-paralogs and out-paralogs]]
[[Image:otu.png|thumb|right|500px|Diagram depicting evolutionary relationship between orthologs, in-paralogs and out-paralogs]]


Genes arising from gene duplication in given specie without any intervening speciation event. Paralogous genes tend to have different functions and contribute to the overall genetic diversity of an organism. However, paralogs can sometimes undergo a phenomenon known as gene conversion, where one paralog's sequence is converted to another's sequence, making them identical. Therefore, for two very similar protein sequences in an organism, gene conversion should be taken into account when constructing phylogenomic trees.
In-paralogous genes are essentially [[paralogous]] genes.  The nomenclature helps in distinguishing different classes of genes derived from the divergence of lineages (aka events leading to speciation) and the duplication within a lineage when multiple taxa are compared. Specifically, in helps identify cases where two lineages share a gene duplication, but each lineage loses the reciprocal paralog. These genes may be mistakenly be called [[orthologs]] when they are [[out-paralogs]].

Latest revision as of 22:49, 4 February 2011

Diagram depicting evolutionary relationship between orthologs, in-paralogs and out-paralogs

In-paralogous genes are essentially paralogous genes. The nomenclature helps in distinguishing different classes of genes derived from the divergence of lineages (aka events leading to speciation) and the duplication within a lineage when multiple taxa are compared. Specifically, in helps identify cases where two lineages share a gene duplication, but each lineage loses the reciprocal paralog. These genes may be mistakenly be called orthologs when they are out-paralogs.