Global alignment: Difference between revisions
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Global alignment allows sequences to be aligned from start to end. A scoring matrix is build with ''n'' sequences aligned on ''n ''axes. Each entry in a given cell is matched with corresponding entries in''n'' dimensions. Consequently, each cell has a score depending upon the threshold values selected for registering a match or a mismatch. A pointer is drawn in a cell that indicates the direction from which the highest score was obtained. In the end, starting from bottom right of matrix the arrows are back tracked to the origin. This gives the best order in which ''n'' sequences should be globally aligned. | Global alignment allows sequences to be aligned from start to end. A scoring matrix is build with ''n'' sequences aligned on ''n ''axes. Each entry in a given cell is matched with corresponding entries in ''n'' dimensions. Consequently, each cell has a score depending upon the threshold values selected for registering a match or a mismatch. A pointer is drawn in a cell that indicates the direction from which the highest score was obtained. In the end, starting from bottom right of matrix the arrows are back tracked to the origin. This gives the best order in which ''n'' sequences should be globally aligned. | ||
Revision as of 22:12, 25 September 2009
Global alignment allows sequences to be aligned from start to end. A scoring matrix is build with n sequences aligned on n axes. Each entry in a given cell is matched with corresponding entries in n dimensions. Consequently, each cell has a score depending upon the threshold values selected for registering a match or a mismatch. A pointer is drawn in a cell that indicates the direction from which the highest score was obtained. In the end, starting from bottom right of matrix the arrows are back tracked to the origin. This gives the best order in which n sequences should be globally aligned.