GC content shift

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GC content shift is an evolutionary genome-wide change in the GC content of an organism. The evolutionary consequences of such a change is unknown. They are detected by comparing the genomes of two related organisms that share a recent common ancestor, and determining if their have different:

  • AT/GC genomic composition
  • High rate of synonymous mutations for syntenic gene pairs
  • Amino acid usage frequencies
  • Codon usage frequencies
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