Bacteria Genomic Inversion

Syntenic dotplot between substrains DH10B and W3110 of Escherichia coli K12. The inversion is shown by the red line that is off-set from the green line. Results can be regenerated in SynMap at Master 4241 4243.CDS-CDS.blastn geneorder D20 g10 A5.w500.png.

It is easy to visualize genomic inversions with a syntenic dotplot. Since syntenic regions appear as colored lines in the syntenic dotplot generated by SynMap, inversions are seen when a syntenic line has a discontinuity or break, and there is an adjacent line with an opposite slope (e.g. a positively sloping line has a break and adjacent to it is a negatively sloping line).

In the example shown here, SynMap colored the syntenic lines green if they have a positive slope and red if they have a negative slope. This plot has a nearly continuous green line starting at the origin in the lower left and sloping to the upper right.