K12 assembly
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Revision as of 19:20, 14 October 2009 by Elyons (Talk | contribs) (Created page with 'Cheap sequencing brings cheap genomes! However, depending on the technology used to sequencing a genome, you will find that even with 50-100x sequencing coverage, a genome canno...')
Cheap sequencing brings cheap genomes! However, depending on the technology used to sequencing a genome, you will find that even with 50-100x sequencing coverage, a genome cannot be completely assembled. Due to repeat regions in the genome that are larger than the reads generated by the sequencing technology, pieces of the genome cannot be ordered relative to one another unless bac-ends are used to anchor these pieces relative to one another. What can CoGe do to help?
Fortunately, when it comes to many microbial genomes, there are already many complete genomes that can be used as a reference. SynMap is the perfect tool for comparing genomes.
