LncRNA Project

Project Overview

Long non-coding RNAs (lncRNAs) function in multiple eukaryotic gene regulatory processes and genome architecture modifications through interaction with specific proteins and/or complexes, including histone modifying enzymes, splicing factors, and matrix proteins. These interactions are specified by secondary structures encoded in the lncRNAs more so than by their primary sequence. Despite our increasing appreciation for the importance of lncRNAs, our knowledge of their structure, protein interactions, and functions is severely lacking, especially in model and crop plant species. Our project will address this significant gap using a combination of genomic, evolutionary, and bioinformatics approaches.

Project PIs

1. Brian Gregory bdgregor@sas.upenn.edu
2. Eric Lyons elyons.uoa@gmail.com
3. Mark Beilstein mbeilstein@gmail.com