Difference between revisions of "Genomic inversion"
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[[Image:1911 1906.CDS-CDS.blastn.dag geneorder D20 g10 A5.1-1.w800.png|thumb|right|500px|Syntenic dotplot generated by [[SynMap]] between two strains of Yersinia pseudotuberculosis showing one inversion. [http://synteny.cnr.berkeley.edu/CoGe/OrganismView.pl?dsgid=1911 Strain IP 31758] (x-axis); [http://synteny.cnr.berkeley.edu/CoGe/OrganismView.pl?dsgid=1906 strain YPIII] (y-axis). Results can be regenerated at: http://synteny.cnr.berkeley.edu/CoGe/SynMap.pl?dsgid1=1911;dsgid2=1906;D=20;g=10;A=5;w=0;b=1;ft1=1;ft2=1;dt=geneorder]] | [[Image:1911 1906.CDS-CDS.blastn.dag geneorder D20 g10 A5.1-1.w800.png|thumb|right|500px|Syntenic dotplot generated by [[SynMap]] between two strains of Yersinia pseudotuberculosis showing one inversion. [http://synteny.cnr.berkeley.edu/CoGe/OrganismView.pl?dsgid=1911 Strain IP 31758] (x-axis); [http://synteny.cnr.berkeley.edu/CoGe/OrganismView.pl?dsgid=1906 strain YPIII] (y-axis). Results can be regenerated at: http://synteny.cnr.berkeley.edu/CoGe/SynMap.pl?dsgid1=1911;dsgid2=1906;D=20;g=10;A=5;w=0;b=1;ft1=1;ft2=1;dt=geneorder]] | ||
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+ | [[Image:Yersinia pseudotuberculosis-inversion-GEvo.png|thumb|right|500px|[[GEvo]] analysis of inversion breakpoints identified in two strains of Yersinia pseudotuberculosis. At the breakpoints are ribosomal gene cassettes (shown as gray and yellow arrows). Results can be regenerated at: http://tinyurl.com/yj38xw6]] | ||
===Definition=== | ===Definition=== |
Revision as of 11:27, 18 February 2010
Definition
A genomic inversion is when a region of a genome or chromosome gets flipped in place. These usually happen at genomic regions with nearly identical sequence, implying a mechanism similar to non-homologous recombination.
Bacteria
In bacterial genomes, inversion often occur at transposon or ribosomal gene sequences, and happen symmetrically around the origin of replication. The latter causes a characteristic pattern in syntenic dotplots called an x alignment.